With the help of clinical partners in the UA Department of Orthopaedic Surgery, Szivek’s lab plans to 3D print scaffolds – plastic bone-shaped frames – that can replace large, missing or broken bone segments. These scaffolds will be filled with calcium particles and adult stem cells, two key elements that lead to much faster healing and bone growth. Once implanted, the scaffold will serve as a template for the bone to grow on.
Pilot studies in Szivek’s lab have shown this technique works well. “We achieved complete bone formation, covering a large bone defect in about three months. Now we want to make that healing process even faster,” he said. The team will test whether exercise early in the healing process can help speed up healing and recovery. “Studies have shown that exercise makes your bones grow, so maybe we can make bone on our scaffolds grow even faster with exercise,” Szivek said. To test this theory, the 3D implants will be embedded with tiny sensors that can wirelessly transmit exercise activity. These sensors will analyze loading, or how much weight is being put on the scaffold, and for what length of time.
Helping military personnel
Bone size changes in an active group that regularly exercises will be compared with an inactive group. Szivek’s team expects to see that the active group that regularly put weight on their healing limbs will show much quicker bone growth. His team hopes to develop guidelines for post-surgical physical therapy by demonstrating that exercise leads to better bone formation.
If the study is successful, Szivek anticipates the clinical trials will take place in military personnel. Current treatment of these traumatic injuries usually fails and requires repeated surgeries. “Patients often re-break the damaged bone area after surgeons try to repair it and the limb will eventually be amputated,” Szivek explained. “There’s just no good way of regenerating or re-growing long bone segments right now.”
The human body will attempt to re-grow missing or damaged bone for a few months after an injury, but it eventually gives up on the process. At that point, scar tissue fills the defect instead of bone. “That’s why we need to develop a way to grow bone as quickly as possible – to help the body while it is still able to grow and replace the bone,” Szivek said. He hopes the potential therapy also will help patients with bone cancers that are removed operatively.