A next generation material for skin-healing.
A next generation material for skin-healing.
Source: MA Kun

Nano-scale borate bioactive glass for skin-healing

With the help of a steady-state strong magnetic field experimental device, researchers have constructed a nano-scale borate bioactive glass that can effectively reduces the biological toxicity of borate bioglass and improves the biocompatibility of the glass.

"It is expected to become the next generation of skin wound repair dressings,” said Professor Wang Junfeng from High Magnetic Field Laboratory, Hefei Institutes of Physical Science (HFIPS).

Borate bioglass is a glass with boron element (B) as the glass network matrix. With good dopability and degradability, it has great potential in the field of skin tissue repair. However, some unresolved problems hindered its development: It releases a large amount of alkaline ions, and the explosive release of these ions will change the acid-base environment of the tissue around the glass material, thereby inhibiting cell proliferation. In addition, the effective surface area of micron-sized borate bioglass in contact with tissues at the wound is small, and the ions on the glass surface are not conducive to the deposition of collagen, so scars are easily formed at the wound after healing. Therefore, preparing a nano-scale borate bioglass with no biological toxicity and excellent biological performance is an urgent problem to be solved.

In this study, researchers used a special mobile phase, for the first time, to pre-treat micron-sized borate bioglass by melting method in vitro. They successfully obtained Nano-scale (~50nm) borate bioglass (Nano-HCA@BG), which was covered with an amorphous HCA layer. During the processing, the ions (PO43- and CO32-) in the mobile phase were deposited on the surface of the glass to form an amorphous HCA layer, which effectively inhibited the rapid release of boron and calcium in the remaining glass and thereby reduced the biological toxicity of the glass itself to cells. In addition, HCA, as an important inorganic component in bones, has good biocompatibility, and can accelerate the induction of collagen synthesis in tissues.

The wound healing process of a mouse skin defect model. (A) Different control...
The wound healing process of a mouse skin defect model. (A) Different control group and Nano-HCA@BG mice skin wound healing images on days 0, 1, 3, 5, and 7 (the unit scale of the ruler in the photo is 1mm). (B) Corresponding statistical results of wound healing rate in mice.
Source: MA Hui

The results of in vitro degradation experiments, cell experiments, and animal experiments showed that compared with the existing commercialized 45S5, Hydroxyapatite and micron-sized borate bioglass, nano-HCA@BG slow-released boron calcium, and other elements can effectively accelerate wound cells migration and further up-regulation of the expression of vascular-related growth factors in the wound. Besides, the amorphous HCA layer on the surface of the glass not only reduces the rapid release of the glass, but also promotes the deposition of collagen in the wound, which in turn promotes the healing of the wound more quickly.

The research was published in the Chemical Engineer Journal.

Subscribe to our newsletter

Related articles

Nano-thin piezoelectrics advance wearables

Nano-thin piezoelectrics advance wearables

A new type of ultra-efficient, nano-thin material could advance self-powered electronics, wearable technologies and even deliver pacemakers powered by heart beats.

Altering the properties of 2D materials at the nanometer scale

Altering the properties of 2D materials at the nanometer scale

Scientists have developed a method for changing the physical properties of 2D materials permanently using a nanometric tip.

Magnetic nanopropellers deliver genetic material to cells

Magnetic nanopropellers deliver genetic material to cells

Researchers at the Max Planck Institute for Intelligent Systems in Germany have developed powerful nanopropellers that can be steered into the interior of cells to deliver gene therapy.

Printable rubber-like material could replace human tissue

Printable rubber-like material could replace human tissue

Researchers have created a material with a unique set of properties, which could act as a replacement for human tissue in medical procedures.

Bioengineering living heart valves

Bioengineering living heart valves

Reserchers have made progress developing living heart valves that can grow with the body and integrate with the patient's native tissue.

Tuning collagen threads for biohybrid robots

Tuning collagen threads for biohybrid robots

Researchers are taking steps to incorporate actual muscles or neurons into a robotic system.

Skeletal scaffold supports bone cells

Skeletal scaffold supports bone cells

3D models of bone formation provide a tool for tissue engineering, biomedical research and drug testing.

All your digital photos could be stored as DNA

All your digital photos could be stored as DNA

Biological engineers have demonstrated a way to easily retrieve data files stored as DNA. This could be a step toward using DNA archives to store enormous quantities of photos, images, and other digital content.

Bioprinter speeds up drug development

Bioprinter speeds up drug development

A 3D printer that rapidly produces large batches of custom biological tissues could help make drug development faster and less costly.

Popular articles

Subscribe to Newsletter