Nerve-on-a-chip improves neuroprosthetics

Nerve-on-a-chip improves neuroprosthetics

Scientists have developed a miniaturized electronic platform for the stimulation and recording of peripheral nerve fibers-on-a-chip.

Neuroprosthetics – implants containing multi-contact electrodes that can substitute certain nerve functionalities – have the potential to work wonders. They may be able to restore amputees’ sense of touch, help the paralyzed walk again by stimulating their spinal cords and silence the nerve activity of people suffering from chronic pain. Stimulating nerves at the right place and the right time is essential for implementing effective treatments, but still a challenge due to implants’ inability to record neural activity precisely. “Our brain sends and receives millions of nerve impulses, but we typically implant only about a dozen electrodes in patients. This type of interface often doesn’t have the resolution necessary to match the complex patterns of information exchange in a patient’s nervous system,” says Sandra Gribi, a PhD student at the Bertarelli Foundation Chair in Neuroprosthetic Technology.

Replicating – and improving – how neuroprosthetics work

Scientists at the lab run by Dr. Stéphanie Lacour, a professor at EPFL’s School of Engineering, have developed a nerve-on-a-chip platform that can stimulate and record from explanted nerve fibers, just as an implanted neuroprosthetic would. Their platform contains microchannels embedded with electrodes and explanted nerve fibers faithfully replicate the architecture, maturity and functioning of in vivo tissue.

The scientists tested their platform on explanted nerve fibers from rats’ spinal cords, trying out various strategies for stimulating and inhibiting neural activity. “In vitro tests are usually carried out on neuron cultures in dishes. But these cultures don’t replicate the diversity of neurons, like their different types and diameters, that you would find in vivo. Resulting nerve cells’ properties are changed. What’s more, the extracellular microelectrode arrays that some scientists use generally can’t record all the activity of a single nerve cell in a culture,” says Gribi.

The nerve-on-a-chip platform developed at EPFL can be manufactured in a clean room in two days and is able to rapidly record hundreds of nerve responses with a high signal-to-noise ratio. However, what really sets it apart is that it can record the activity of individual nerve cells.

The scientists used their platform to test a photothermic method for inhibiting neural activity. “Neural inhibition could be a way to treat chronic pain like the phantom limb pain that appears after an arm or leg has been amputated, or neuropathic pain,” says Lacour.

The scientists deposited a photothermic semiconducting polymer, called P3HT:PCBM, on some of the chip’s electrodes. “The polymer heats up when subject to light. Thanks to the sensitivity of our electrodes, we were able to measure a difference in activity between the various explanted nerve fibers. More specifically, the activity of the thinnest fibers was dominantly blocked,” says Gribi. And it’s precisely those thin fibers that are nociceptors – the sensory neurons that cause pain. The next step will be to use the polymer in an implant placed around a nerve to study the inhibiting effect in vivo.

The scientists also used their platform to improve the geometry and position of recording electrodes, in order to develop an implant that can regenerate peripheral nerves. By running the measured neural data through a robust algorithm, they will be able to calculate the speed and direction of nerve impulse propagation – and therefore determine whether a given impulse comes from a sensory or motor nerve. “That will enable engineers to develop bidirectional, selective implants allowing for more natural control of artificial limbs such as prosthetic hands,” says Lacour.

Subscribe to our newsletter

Related articles

Thoughts could control electronic prostheses

Thoughts could control electronic prostheses

Researchers have been working to advance a technology that could one day help people with paralysis regain use of their limbs, and enable amputees to use their thoughts to control prostheses.

The concept of creating a 'brain-on-a-chip'

The concept of creating a 'brain-on-a-chip'

Scientists have proposed the concept of a memristive neurohybrid chip to be used in compact biosensors and neuroprostheses.

Implants: Next-generation brain interfaces

Implants: Next-generation brain interfaces

Next-generation brain implants with more than a thousand electrodes can survive for more than six years.

Prostheses could alleviate amputees' phantom limb pain

Prostheses could alleviate amputees' phantom limb pain

New prosthetic technologies that stimulate the nerves could pave the way for prostheses that feel like a natural part of the body and reduce the phantom limb pain commonly endured by amputees.

Integrate micro chips for electronic skin

Integrate micro chips for electronic skin

First fully integrated flexible electronics made of magnetic sensors and organic circuits opens the path towards the development of electronic skin.

Robotic hand merges amputee and robotic Control

Robotic hand merges amputee and robotic Control

Scientists have successfully tested neuroprosthetic technology that combines robotic control with users’ voluntary control, opening avenues in the new interdisciplinary field of shared control for neuroprosthetic technologies.

Circuit implants release painkillers inside the body

Circuit implants release painkillers inside the body

Researchers have developed biodegradable microresonators that could soon be used in implants to control the release of painkillers within tissue.

Prosthetics: sensors implanted for wireless control of muscle signal

Prosthetics: sensors implanted for wireless control of muscle signal

Researchers have successfully implanted sensors in three male patients following nerve transfers, to transmit biosignals for wireless control of robotic arms.

Brain-computer interface enables paralysed to control tablets

Brain-computer interface enables paralysed to control tablets

Research from the BrainGate consortium shows that a brain-computer interface (BCI) can enable people with paralysis to directly operate an off-the-shelf tablet device just by thinking about making cursor movements and clicks.

Popular articles