genetics

CRISPRoff offers unrivaled control of epigenetic inheritance

Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome.

Explainable AI for decoding genome biology

Researchers have developed advanced explainable AI in a technical tour de force to decipher regulatory instructions encoded in DNA.

How genetic motifs conduct "the music of life"

Using AI and supercomputers, researchers have discovered reoccurring patterns and combinations of the four molecular building blocks A, C, G and T.

Genome-editing tool TALEN outperforms CRISPR-Cas9

Experiments revealed that TALEN is up to five times more efficient than CRISPR-Cas9 in parts of the genome that are densely packed.

CRISPR to cure sickle cell disease

University of Illinois Chicago is one of the U.S. sites participating in clinical trials to cure severe red blood congenital diseases such as sickle cell anemia or Thalassemia by safely modifying the DNA of patients’ blood cells.

Precision health in the palm of your hand

Recent breakthrough developments in technologies for real-time genome sequencing, analysis, and diagnosis are poised to deliver a new standard of personalized care.

Star Trek: DNA “tricorder” for your pocket

Scientists developed the world’s first mobile genome sequence analyzer, a new iPhone app called iGenomics.

Robots are helping to advance developmental biology

Scientists are using a custom robot to survey how mutations in regulatory regions of the genome affect animal development.

AI offers clues to a 500-year old mystery

Researchers used AI and genetic analyses to examine the structure of the inner surface of the heart using 25 000 MRI scans.

Using CRISPR to knock down gene messages

Researchers have harnessed CRISPR technology to target gene messages (messenger RNA) involved in early vertebrate

Genetic diseases research with quantum computing

Scientists are harnessing the mind-bending potential of quantum computers to help us understand genetic diseases – even before quantum computers are a thing.

Janggu makes deep learning a breeze

Researchers have developed a new tool that makes it easier to maximize the power of deep learning for studying genomics.

AI finds disease-related genes

An artificial neural network can reveal patterns in huge amounts of gene expression data, and discover groups of disease-related genes.

Using CRISPR to detect diseases

Researchers present sensor prototype that can rapidly, precisely, and cost-effectively measure molecular signals for cancer.

Revolutionising CRISPR-Cas

Researchers have refined the famous CRISPR-Cas method. Now, for the very first time, it is possible to modify dozens, if not hundreds, of genes in a cell simultaneously.

AI helps determine human biological age

Scientists participating in the project “DrugTarget” have now developed a method that can quickly check the condition of the genome. This will help develop points of intervention for new medicines

AI detects rare diseases

With artificial intelligence to a diagnosis of rare hereditary diseases: The neural network combines data from portrait images with gene and patient data.

Machine learning makes proteomics research more effective

Using AI, researchers have succeeded in making the mass analysis of proteins from any organism significantly faster than before and almost error-free.

AI detects a new class of mutations behind autism

Using artificial intelligence, researchers have decoded the functional impact of genome mutations in people with autism spectrum disorder.

CRISPR-powered device detects genetic mutations in minutes

Engineers have combined CRISPR with electronic transistors made from graphene to create a new hand-held device that can detect specific genetic mutations in a matter of minutes.

CasX, the smaller CRISPR gene editor

Scientists find new and smaller gene editor: the new gene-editing protein, CasX, may give CRISPR-Cas9 a run for its money.

CRISPR repurposed to develop better antibiotics

Researchers have repurposed the gene-editing tool CRISPR to study which genes are targeted by particular antibiotics, providing clues on how to improve existing antibiotics or develop new ones.

CRISPR: Giving Cas9 an ‘on’ switch

Researchers have given CRISPR-Cas9 an “on” switch, allowing users to keep the #Cas9 gene editor turned off in all cells except its designated target.

Could an AI predict a healthy old age?

Researchers analyze skin cells from mre than 100 people of different ages to find molecular signatures that change as people get older.

Big datasets help identify causes for pediatric diseases

Researchers use the analogy of raindrops on the sidewalk to explain their new method to identify genetic variations that cause severe pediatric diseases.

CRISPR opens door to new therapy options- ‘genome surgery’

Scientists plan to edit their genomes to correct rare genetic mutations and slow or halt progression of their diseases.

Liver-on-a-chip, the ideal test environment for CRISPR

Research project is aimed at improving therapeutic options for both rare and common diseases, including supporting methods to improve editing the human genome.

“Brain-on-a-Chip” reveals how the brain folds

Researchers describe a method they developed for growing tiny “brains on chips” from human cells that enabled them to track the physical and biological mechanisms underlying the wrinkling process.